I’ve just upgraded to Fedora Workstation 42 and am now unable to activate any GNOME extensions. The little switches in the GUI do not respond and it’s the same for all extensions. The Extensions and Extensions Manager apps are both installed as flatpaks - do I need to adjust their permissions in Flatseal? Is the problem due to something else? Thanks!
Edit/solution: I totally missed the ‘Use Extensions’ switch at the very top. All my extensions are working on the current GNOME version (48) now. I am the most silly. Hopefully the other solutions in the comments will be useful to someone else in future :)
I know that OP already found the solution but I just wanted to chime in because every person who commented completely misunderstood the question. It’s normal that some extenions don’t support the new version after updating GNOME but in that case, the switch will be disabled and it will show you a warning that the extensions doesn’t support the new GNOME version. OP clearly stated that they could still switch the extensions on and off. Besides that, most extensions will already have been updated to support the new version by the time the Fedora update comes out, so it wouldn’t make sense that all the extensions wouldn’t work anymore.
As a tip, you can install “Extension Manager” instead of the default “Extenions” app and besides being able to install extensions right through the app, it also has an “Upgrade Assistant” function, which lets you check which of your extensions support the GNOME version you specify. That way you can check if your extensions will work in the new GNOME version before updating.